BDBM579897 (S)-N1- (3-(3,4- dihydro- isoquinolin- 2(1H)- yl)-2- hydroxy- propyl)- N4,N4- dimethyl::US11485731, Example 1AX

SMILES CN(C)C(=O)C1CCN(CC1)C(=O)NC[C@H](O)CN1CCc2ccccc2C1

InChI Key InChIKey=AFRGCGVTMLVORG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 579897   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Argonaut Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 579897BDBM579897(US11485731, Example 1AX | (S)-N1- (3-(3,4- dihydro...)
Affinity DataIC50: 588nMAssay Description:A PRMT5 chemiluminescent assay was used to measure the IC50 activity of PRMT5 of the compounds of Examples 1A to 7 above. Biotinylated histone peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent