BDBM579947 3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl thiomorpholine-4-carboxylate (Prepared according to Scheme 5)::US11485731, Example 4A

SMILES OC(COC(=O)N1CCSCC1)CN1CCc2ccccc2C1

InChI Key InChIKey=VFBPQTAHRSPLRG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 579947   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Argonaut Therapeutics

US Patent
LigandPNGBDBM579947(US11485731, Example 4A | 3-(3,4-dihydroisoquinolin...)
Affinity DataIC50: 477nMAssay Description:A PRMT5 chemiluminescent assay was used to measure the IC50 activity of PRMT5 of the compounds of Examples 1A to 7 above. Biotinylated histone peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
Go to US Patent