BDBM579987 (R)-N-((S)-3-(3,4- dihydroisoquinolin- 2(1H)-yl)-2- hydroxypropyl)- 3-(tetrahydro- 2H-pyran-4-yl) piperidine-1- carboxamide compound or (S)-N-((S)-3-(3,4- dihydroisoquinolin- 2(1H)-yl)-2- hydroxypropyl)-::US11485731, Example 5G::US11485731, Example 5H

SMILES O[C@@H](CNC(=O)N1CCC[C@H](C1)C1CCOCC1)CN1CCc2ccccc2C1

InChI Key InChIKey=BNIVCVQORGPNBY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 579987   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Argonaut Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 579987BDBM579987(US11485731, Example 5G | (R)-N-((S)-3-(3,4- dihyd...)
Affinity DataIC50: 394nMAssay Description:A PRMT5 chemiluminescent assay was used to measure the IC50 activity of PRMT5 of the compounds of Examples 1A to 7 above. Biotinylated histone peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Argonaut Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 579987BDBM579987(US11485731, Example 5G | (R)-N-((S)-3-(3,4- dihyd...)
Affinity DataIC50: 511nMAssay Description:A PRMT5 chemiluminescent assay was used to measure the IC50 activity of PRMT5 of the compounds of Examples 1A to 7 above. Biotinylated histone peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent