BDBM581732 US11512080, Compound I-20

SMILES c1ccc(cc1)N2CCC(=O)NC2=O

InChI Key InChIKey=IYBINJWRHRKLTJ-UHFFFAOYSA-N

Data  2 IC50  1 Kd  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 581732   

TargetProtein cereblon(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 581732BDBM581732(US11512080, Compound I-20)
Affinity DataKd:  5.60E+3nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetProtein cereblon(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 581732BDBM581732(US11512080, Compound I-20)
Affinity DataIC50: 8.00E+3nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetZinc finger protein Aiolos(Homo sapiens)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 581732BDBM581732(US11512080, Compound I-20)
Affinity DataEC50: >1.00E+4nMAssay Description:Induction of ePL tagged Aiolos degradation in human DF15 cells incubated for 4 hrs by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetProtein cereblon(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 581732BDBM581732(US11512080, Compound I-20)
Affinity DataIC50: 5.50E+4nMAssay Description:Equal volumes of His-tagged CRBN-DDB1 complex (56 nM) was mixed with Eu-cryptate labeled Anti-6HIS-monoclonal antibody (50× dilution from the commerc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent