BDBM5931 BMS-387072::CHEMBL296468::N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide::N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide::cid_3025986
SMILES CC(C)(C)c1cnc(o1)CSc2cnc(s2)NC(=O)C3CCNCC3
InChI Key InChIKey=OUSFTKFNBAZUKL-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 882 hits for monomerid = 5931
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Westfalian Wilhelms University Muenster (WWU)
Curated by ChEMBL
Westfalian Wilhelms University Muenster (WWU)
Curated by ChEMBL
Affinity DataKd: 1.70nMAssay Description:Binding constant for CDKL5 kinase domainMore data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Westfalian Wilhelms University Muenster (WWU)
Curated by ChEMBL
Westfalian Wilhelms University Muenster (WWU)
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of human CDK9 (2 to 372 residues)/cyclin T1 (2 to 726 residues) expressed in baculovirus-infected Sf9 insect cell expression systemMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of CDK9/Cyclin TMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of CDK9/Cyclin T (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human full length C-terminal His6-tagged CDK9/cyclin T1 expressed in baculovirus infected Sf21 insect cells using PDKtide a...More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Westfalian Wilhelms University Muenster (WWU)
Curated by ChEMBL
Westfalian Wilhelms University Muenster (WWU)
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of CDK9/cyclin T1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3 [D835Y](Human)
Ambit Biosciences
Curated by PubChem BioAssay
Ambit Biosciences
Curated by PubChem BioAssay
Affinity DataKd: 5.20nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant human full-length His-tagged CDK9/Cyclin T1 expressed in baculovirus infection system using Cdk7/9tide as substrate measure...More data for this Ligand-Target Pair
Affinity DataKd: 7.10nMAssay Description:Binding constant for PCTK1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 7.10nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 7.10nMAssay Description:Binding constant for PCTK1 kinase domainMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Westfalian Wilhelms University Muenster (WWU)
Curated by ChEMBL
Westfalian Wilhelms University Muenster (WWU)
Curated by ChEMBL
Affinity DataIC50: 7.80nMAssay Description:Inhibition of CDK9/CyclinT1 (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Affinity DataKd: 13nMAssay Description:Binding constant for full-length PCTK2More data for this Ligand-Target Pair
Affinity DataKd: 13nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 13nMAssay Description:Binding constant for PCTK2 kinase domainMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-tagged CDK2/cyclinA1 expressed in baculovirus infected Sf9 insect cells using FRET-labeled...More data for this Ligand-Target Pair
Affinity DataKd: 23nMAssay Description:Binding constant for CDC2L5 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 28nMAssay Description:Binding constant for GSK3A kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 28nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 28nMAssay Description:Binding constant for full-length GSK3AMore data for this Ligand-Target Pair
Affinity DataKd: 31nMAssay Description:Binding constant for CDK7 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 31nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 31nMAssay Description:Binding constant for full-length CDK7More data for this Ligand-Target Pair
Affinity DataKd: 37nMAssay Description:Binding constant for GSK3B kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 37nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 37nMAssay Description:Binding constant for full-length GSK3BMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
University of South Australia Cancer Research Institute
Curated by ChEMBL
University of South Australia Cancer Research Institute
Curated by ChEMBL
Affinity DataIC50: 38nMAssay Description:Inhibition of GST-tagged CDK2/Cyclin E (unknown origin) expressed in baculovirus expression system using GST-pRb (776 to 928 residues) as substrate m...More data for this Ligand-Target Pair
Affinity DataKi: 38nMAssay Description:Inhibition of human CDK2 after 30 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
University of Nebraska Medical Center
Curated by ChEMBL
University of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: 38nMAssay Description:Inhibition of human full length C-terminal His6-tagged CDK2/N-terminal GST-tagged cyclin A expressed in baculovirus infected Sf21 insect cells using ...More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
University of Nebraska Medical Center
Curated by ChEMBL
University of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: 38nMAssay Description:Inhibition of C-terminal His6-tagged human full length CDK2/cyclin A expressed in Sf21 insect cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Inhibition of CDK2/cyclin A by IMAP florescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of CDK9/cyclinT by IMAP florescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKd: 41nMAssay Description:Binding constant for CDKL2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 44nMAssay Description:Binding constant for PCTK3 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 44nMAssay Description:Binding constant for full-length PCTK3More data for this Ligand-Target Pair
Affinity DataKd: 44nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataIC50: 46nMAssay Description:Inhibition of CDK2/Cyclin A by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
University of South Australia Cancer Research Institute
Curated by ChEMBL
University of South Australia Cancer Research Institute
Curated by ChEMBL
Affinity DataIC50: 48nMAssay Description:Inhibition of recombinant human full length C-terminal His6-tagged CDK2/N-terminal GST-tagged cyclin E expressed in baculovirus infected Sf21 insect ...More data for this Ligand-Target Pair
Affinity DataKd: 48nMAssay Description:Binding constant for CDC2L2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 48nMAssay Description:Binding constant for CDC2L2 kinase domainMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
University of South Australia Cancer Research Institute
Curated by ChEMBL
University of South Australia Cancer Research Institute
Curated by ChEMBL
Affinity DataIC50: 48nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
University of South Australia Cancer Research Institute
Curated by ChEMBL
University of South Australia Cancer Research Institute
Curated by ChEMBL
Affinity DataIC50: 48nMAssay Description:Inhibition of CDK2/cyclinE (unknown origin)More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Westfalian Wilhelms University Muenster (WWU)
Curated by ChEMBL
Westfalian Wilhelms University Muenster (WWU)
Curated by ChEMBL

3D Structure (crystal)