BDBM594469 US11584747, Example 275::US11584747, Example 276

SMILES CC[C@@H]1CN([C@@H](CC)CN1C(C)c1ccc(CN2CCOC(C)(C)C2)cc1)c1nc(=O)n(C)c2ccc(nc12)C#N

InChI Key InChIKey=NXVOTKGLEWJUOJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 594469   

TargetDiacylglycerol kinase alpha [9-727](Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM594469(US11584747, Example 275 | US11584747, Example 276)
Affinity DataIC50: 120nMAssay Description:The reactions were carried out in 50 mM MOPS pH 7.5, 100 mM NaCl, 10 mM MgCl2, 1 μM CaCl2, and 1 mM DTT (assay buffer). The reactions using a de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM594469(US11584747, Example 275 | US11584747, Example 276)
Affinity DataIC50: 150nMAssay Description:The reactions were carried out in 50 mM MOPS pH 7.5, 100 mM NaCl, 10 mM MgCl2, 1 μM CaCl2, and 1 mM DTT (assay buffer). The reactions using a de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetDiacylglycerol kinase alpha [9-727](Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM594469(US11584747, Example 275 | US11584747, Example 276)
Affinity DataIC50: 530nMAssay Description:The reactions were carried out in 50 mM MOPS pH 7.5, 100 mM NaCl, 10 mM MgCl2, 1 μM CaCl2, and 1 mM DTT (assay buffer). The reactions using a de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM594469(US11584747, Example 275 | US11584747, Example 276)
Affinity DataIC50: 1.38E+3nMAssay Description:The reactions were carried out in 50 mM MOPS pH 7.5, 100 mM NaCl, 10 mM MgCl2, 1 μM CaCl2, and 1 mM DTT (assay buffer). The reactions using a de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent