BDBM596310 (1-(3-((4a,8a- dihydroisoquinolin- 6-yl)thio)-1H- pyrazolo[3,4- b]pyrazin-6-yl)-4- methylpiperidin-4- yl)methanamine::US11591336, Compound 514

SMILES CC1(CN)CCN(CC1)c1cnc2c(SC3=CC4C=CN=CC4C=C3)n[nH]c2n1

InChI Key InChIKey=YLRNLUCIIJHVEL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 596310   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
D. E. Shaw Research

US Patent
LigandPNGBDBM596310((1-(3-((4a,8a- dihydroisoquinolin- 6-yl)thio)-1H- ...)
Affinity DataIC50: 1.00E+3nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2023
Entry Details
US Patent