BDBM599339 5-{4-amino-5-[(3- aminoazetidin-1- yl)methyl]pyrrolo[2,1- f][1,2,4]triazin-7- yl}-N[(3R,4S)-4- fluoro-1-(3,3,3- trifluoro-2- hydroxypropyl) pyrrolidin-3-yl]-2- methoxypyridine-3- carboxamide::US11618753, Example 482

SMILES COc1ncc(cc1C(=O)N[C@@H]1CN(CC(O)C(F)(F)F)C[C@@H]1F)-c1cc(CN2CC(N)C2)c2c(N)ncnn12

InChI Key InChIKey=SYKOELYPNMEUOX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 599339   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM599339(US11618753, Example 482 | 5-{4-amino-5-[(3- aminoa...)
Affinity DataIC50: 4.00E+4nMAssay Description:A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPK1(1-324) in FRET Buffer (20 mM HEP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2023
Entry Details
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