BDBM599466 5-[4-amino-5- (trifluoromethyl)pyrrolo[2,1- f][1,2,4]triazin-7-yl]-3-fluoro-N- [(3R,4S)-4-fluoro-1-(3,3,3- trifluoro-2- methylpropanoyl)pyrrolidin-3- yl]-2-(fluoromethyl)benzamide::US11618753, Example 627

SMILES CC(C(=O)N1C[C@H](F)[C@@H](C1)NC(=O)c1cc(cc(F)c1CF)-c1cc(c2c(N)ncnn12)C(F)(F)F)C(F)(F)F

InChI Key InChIKey=MYAYIXVQACDODP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 599466   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM599466(US11618753, Example 627 | 5-[4-amino-5- (trifluoro...)
Affinity DataIC50: 7.10E+3nMAssay Description:A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPK1(1-324) in FRET Buffer (20 mM HEP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2023
Entry Details
US Patent