BDBM605736 (1R)-8-[8-(2,3-dichlorophenyl)imidazo[1,5-a]pyridin-5-yl]-8-azaspiro[4.5]decan-1-amine ::US11673901, Compound 5

SMILES N[C@@H]1CCCC11CCN(CC1)c1ccc(-c2cccc(Cl)c2Cl)c2cncn12

InChI Key InChIKey=HLICNWYKEXNCRP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 605736   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Revolution Medicines

US Patent
LigandPNGBDBM605736(US11673901, Compound 5 | (1R)-8-[8-(2,3-dichloroph...)
Affinity DataIC50: 500nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.00005-10 μM) was monitored using an assay in which 0.2 nM of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent