BDBM606715 US11685732, Compound I-359

SMILES COc1ccc(CN(C)C(=O)NC2CCC(CS(=O)(=O)NNC(=O)c3cc(cc(Cl)c3F)-c3cn(C)cn3)C2)cc1

InChI Key InChIKey=CIKBFTZNNWUQDF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 606715   

TargetHistone acetyltransferase KAT7(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 606715BDBM606715(US11685732, Compound I-359)
Affinity DataIC50: 1.00E+4nMAssay Description:Enzyme assay buffer was 50 mM Tris pH 8.0, 0.002% Tween20, 0.005% bovine skin gelatin, and 1 mM dithiothreitol (DTT). For determination of IC50values...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
US Patent

TargetHistone acetyltransferase KAT6A [507-778](Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 606715BDBM606715(US11685732, Compound I-359)
Affinity DataIC50: 1.00E+4nMAssay Description:KAT-6A. Enzyme assay buffer was 50 mM Tris pH 8.0, 0.002% Tween20, 0.005% bovine skin gelatin, and 1 mM dithiothreitol (DTT). For determination of IC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
US Patent

TargetHistone acetyltransferase KAT5(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 606715BDBM606715(US11685732, Compound I-359)
Affinity DataIC50: 1.00E+4nMAssay Description:Enzyme assay buffer was 50 mM Tris pH 8.0, 0.002% Tween20, 0.005% bovine skin gelatin, and 1 mM dithiothreitol (DTT). For determination of IC50values...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
US Patent

TargetHistone acetyltransferase KAT8(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 606715BDBM606715(US11685732, Compound I-359)
Affinity DataIC50: 3.00E+4nMAssay Description:Enzyme assay buffer was 50 mM Tris pH 8.0, 0.002% Tween20, 0.005% bovine skin gelatin, and 1 mM dithiothreitol (DTT). For determination of IC50values...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
US Patent