BDBM610065 N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-6-((3-iodophenyl)amino)nicotinamide::US9701664, Example 38

SMILES Cc1ccc(NC(=O)c2ccc3OCCOc3c2)cc1NC(=O)c1ccc(Nc2cccc(I)c2)nc1

InChI Key InChIKey=ZMLNHBRSYCJSCZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 610065   

TargetHeat shock factor protein 1(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM610065(N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamid...)
Affinity DataIC50: 41nMAssay Description:U2OS cells (5-8×104 cells/mL) or SK-OV-3 cells (5-8×104 cells/mL) were seeded into 96-well plates and incubated at 37° C. for 48 h. Compounds were th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2023
Entry Details
US Patent

TargetHeat shock factor protein 1(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM610065(N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamid...)
Affinity DataIC50: 46nMAssay Description:U2OS cells (1500 per well) were plated in 40 μL of DMEM media (containing 10% fetal calf serum and 2 mM Glutamax T-1) in costar 384-well plates ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2023
Entry Details
US Patent