BDBM613391 1-[1-(cyanomethyl)-4-(3,3,3- trifluoropropylamino) cyclohexyl]-3- (cyclopropanecarbonylamino) pyrazole-4-carboxamide::US11731943, Example 132

SMILES COC1(CN(C1)[C@H]1CC[C@@](CC#N)(CC1)n1cc(C(N)=O)c(NC(=O)C2CC2)n1)C(F)(F)F

InChI Key InChIKey=SDFVWCABSVPVDX-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 613391   

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandPNGBDBM613391(1-[1-(cyanomethyl)-4-(3,3,3- trifluoropropylamino)...)
Affinity DataKi:  217nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM613391(1-[1-(cyanomethyl)-4-(3,3,3- trifluoropropylamino)...)
Affinity DataKi: >319nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent