BDBM613524 1-[1-(cyanomethyl)-4-[3-(4- ethylphenyl)-3-fluoro-azetidin-1- yl]cyclohexyl]-3- (cyclopropanecarbonylamino) pyrazole-4-carboxamide::US11731943, Example 265

SMILES CCc1ccc(cc1)C1(F)CN(C1)C1CCC(CC#N)(CC1)n1cc(C(N)=O)c(NC(=O)C2CC2)n1

InChI Key InChIKey=CWKJLZLYQNPJNJ-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 613524   

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandPNGBDBM613524(US11731943, Example 265 | 1-[1-(cyanomethyl)-4-[3-...)
Affinity DataKi:  1.10nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM613524(US11731943, Example 265 | 1-[1-(cyanomethyl)-4-[3-...)
Affinity DataKi:  4.20nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent