BDBM614393 US11964950, Compound J-12::US20230270730, Compound J-12

SMILES CCS(=O)(=O)Nc1cc(Cc2cc(C(N)=O)c(Nc3ccc(I)cc3F)n(C)c2=O)ccn1

InChI Key InChIKey=LCKCLGOYJLTPLI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 614393   

TargetMitogen-activated protein kinase kinase kinase 1(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandChemical structure of BindingDB Monomer ID 614393BDBM614393(US20230270730, Compound J-12 | US11964950, Compoun...)
Affinity DataIC50: 2.29E+3nMAssay Description:The MEK1-inhibiting activity of the compounds listed in Table 3 below were evaluated by the fluorescent polarization method as described below.The te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2024
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandChemical structure of BindingDB Monomer ID 614393BDBM614393(US20230270730, Compound J-12 | US11964950, Compoun...)
Affinity DataIC50: 2.29E+3nMAssay Description:The test compound, CRAF (Thermo Fisher Scientific Inc.), MEK1 (Thermo Fisher Scientific Inc.) and ERK2 (Carna Biosciences, Inc.) were mixed in ATP-co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2023
Entry Details
US Patent