BDBM615196 3-[2-(4-cyanophenyl)-1H-indol-3-yl]-N-[(3S,4R)-4-hydroxy-2-oxo-pyrrolidin-3-yl]propanamide (116)::US20230271945, Compound 116

SMILES O[C@@H]1CNC(=O)[C@H]1NC(=O)CCc1c([nH]c2ccccc12)-c1ccc(cc1)C#N

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 615196   

TargetApolipoprotein L1(Homo sapiens)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM615196(3-[2-(4-cyanophenyl)-1H-indol-3-yl]-N-[(3S,4R)-4-h...)
Affinity DataIC50:  600nMAssay Description:Briefly, the AlamarBlue active compound, the resazurin, a blue, water soluble, non-toxic and cell permeable molecule, which can be followed by absorb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetApolipoprotein L1(Homo sapiens)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM615196(3-[2-(4-cyanophenyl)-1H-indol-3-yl]-N-[(3S,4R)-4-h...)
Affinity DataIC50:  600nMAssay Description:Apolipoprotein L1 (APOL1) proteins form potassium-permeable cation pores in the plasma membrane. APOL1 risk variants (G1 and G2) induce greater potas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent