BDBM615212 3-[5-fluoro-2-phenyl-7-(trifluoromethyl)-1H-indol-3-yl]-N-[(3S,4R)-4-hydroxy-2-oxo-pyrrolidin-3-yl]propanamide (132)::US20230271945, Compound 132

SMILES O[C@@H]1CNC(=O)[C@H]1NC(=O)CCc1c([nH]c2c(cc(F)cc12)C(F)(F)F)-c1ccccc1

InChI Key InChIKey=UPLIKQBLXGXNNM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 615212   

TargetApolipoprotein L1(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM615212(3-[5-fluoro-2-phenyl-7-(trifluoromethyl)-1H-indol-...)
Affinity DataIC50: 600nMAssay Description:Apolipoprotein L1 (APOL1) proteins form potassium-permeable cation pores in the plasma membrane. APOL1 risk variants (G1 and G2) induce greater potas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2023
Entry Details
US Patent