BDBM619769 US20230295157, Example 93

SMILES Fc1c(Cl)ccc(c1C1=CC(=O)N2[C@H](CC[C@H]2c2ncc([nH]2)-c2ccnc(c2)-n2cccn2)C1)-n1cnnn1

InChI Key InChIKey=VOYZISZEQQAVDQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 619769   

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619769(US20230295157, Example 93)
Affinity DataIC50: 10.3nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetKallikrein-1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619769(US20230295157, Example 93)
Affinity DataIC50: 3.10nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of human plasma kallikrein. The peptide substrate, Z-Gly-Pro-Arg-AMC (Pur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent