BDBM619951 N-(3-(2-((3S,8aS)-7-(3-Chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)-5-oxo-1,2,3,5,8,8a-hexahydroindolizin-3-yl)-1H-imidazol-4-yl)-1-methyl-1H-pyrazol-4-yl)cyclopropanecarboxamide::US20230295157, Example 275

SMILES Cn1cc(NC(=O)C2CC2)c(n1)-c1c[nH]c(n1)[C@@H]1CC[C@H]2CC(=CC(=O)N12)c1c(F)c(Cl)ccc1-n1cnnn1

InChI Key InChIKey=ZQMGGZLOEIDXMK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 619951   

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619951(US20230295157, Example 275 | N-(3-(2-((3S,8aS)-7-(...)
Affinity DataIC50: 24.4nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetKallikrein-1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619951(US20230295157, Example 275 | N-(3-(2-((3S,8aS)-7-(...)
Affinity DataIC50: 15.6nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of human plasma kallikrein. The peptide substrate, Z-Gly-Pro-Arg-AMC (Pur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent