BDBM628476 (3R)-3-(4-chlorophenyl)-2-[(1S)-1-(4-chlorophenyl)ethyl]-3-(2,3-dihydroxy-2-methylpropoxy)-6-(2- hydroxypropan-2-yl)-2,3-dihydro-1H-isoindol-1-one::US20230338337, Example 6

SMILES C[C@H](N1C(=O)c2cc(ccc2[C@]1(OCC(C)(O)CO)c1ccc(Cl)cc1)C(C)(C)O)c1ccc(Cl)cc1

InChI Key InChIKey=UUZINBSIYDKSFT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 628476   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Otsuka Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 628476BDBM628476((3R)-3-(4-chlorophenyl)-2-[(1S)-1-(4-chlorophenyl)...)
Affinity DataIC50: 120nMAssay Description:Each assay was performed in a final volume of 15 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent