BDBM628611 (3R)-2-[(5-Chloro-1-oxo-1lambda5-pyridin-2-yl)methyl]-3-(4-chlorophenyl)-3-{[1- (hydroxymethyl)cyclopropyl]methoxy}-6-(2-hydroxypropan-2-yl)-2,3-dihydro-1H-isoindol-1-one::US20230338337, Compound 10

SMILES CC(C)(O)c1ccc2c(c1)C(=O)N(Cc1ccc(Cl)c[n+]1[O-])[C@@]2(OCC1(CO)CC1)c1ccc(Cl)cc1

InChI Key InChIKey=JZNFZVXUISXDJZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 628611   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Otsuka Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 628611BDBM628611((3R)-2-[(5-Chloro-1-oxo-1lambda5-pyridin-2-yl)meth...)
Affinity DataIC50: 16nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent