BDBM628647 (3R)-3-(4-Chlorophenyl)-4-fluoro-3-({1-[hydroxy(2H2)methyl]cyclopropyl}(2H2)methoxy)-6-(2- hydroxypropan-2-yl)-2-[(6-methoxypyridin-3-yl)methyl]-2,3-dihydro-1H-isoindol-1-one::US20230338337, Compound 37

SMILES COc1ccc(CN2C(=O)c3cc(cc(F)c3[C@]2(c2ccc(Cl)cc2)C2(O)CC2C)C(C)(C)O)cn1

InChI Key InChIKey=AMPKEICOGLLZKE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 628647   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Otsuka Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 628647BDBM628647((3R)-3-(4-Chlorophenyl)-4-fluoro-3-({1-[hydroxy(2H...)
Affinity DataIC50: 35nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent