BDBM628655 (3R)-3-(4-Chlorophenyl)-4-fluoro-3-{[1-(hydroxymethyl)cyclopropyl]methoxy}-6-(2-hydroxypropan- 2-yl)-2-[(5-methylpyridin-2-yl)methyl]-2,3-dihydro-1H-isoindol-1-one::US20230338337, Compound 28

SMILES Cc1ccc(CN2C(=O)c3cc(cc(F)c3[C@]2(OCC2(CO)CC2)c2ccc(Cl)cc2)C(C)(C)O)nc1

InChI Key InChIKey=CZSJGQSSBQIPSN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 628655   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Otsuka Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 628655BDBM628655((3R)-3-(4-Chlorophenyl)-4-fluoro-3-{[1-(hydroxymet...)
Affinity DataIC50: 14nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent