BDBM628691 6-{[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[1-hydroxy-1-(oxan-4-yl)ethyl]-1-{[1- (hydroxymethyl)cyclopropyl]methoxy}-3-oxo-2,3-dihydro-1H-isoindol-2-yl]methyl}pyridine-3- carbonitrile::US20230338337, Compound 89::US20230338337, Compound 90

SMILES CC(O)(C1CCOCC1)c1cc2C(=O)N(Cc3ccc(cn3)C#N)[C@](OCC3(CO)CC3)(c2c(F)c1)c1ccc(Cl)cc1

InChI Key InChIKey=TWMPEOLEJLTRSB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 628691   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM628691(US20230338337, Compound 89 | 6-{[(1R)-1-(4-chlorop...)
Affinity DataIC50: 11nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM628691(US20230338337, Compound 89 | 6-{[(1R)-1-(4-chlorop...)
Affinity DataIC50: 0.640nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
Go to US Patent