BDBM631692 N-((S)-1-(3-(difluoromethyl)-2-fluorophenyl)-2,2,2- trifluoroethyl)-1-(1-(difluoromethyl)cyclopropyl)-4-(((1R,5S,6s)-3-methyl-3- azabicyclo[3.1.0]hexan-6-yl)amino)-6-oxo-1,6-dihydropyridine-3-carboxamide (Example 275)::US20230348424, Example 275::US20230348424, Example 276

SMILES CN1C[C@H]2[C@@H](C1)[C@@H]2Nc1cc(=O)n(cc1C(=O)N[C@H](c1cccc(C(F)F)c1F)C(F)(F)F)C1(CC1)C(F)F

InChI Key InChIKey=GKIABRPRGOAPOQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 631692   

LigandPNGBDBM631692(US20230348424, Example 275 | US20230348424, Exampl...)
Affinity DataIC50: 361nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
US Patent

LigandPNGBDBM631692(US20230348424, Example 275 | US20230348424, Exampl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
US Patent