BDBM635450 1-(tert-Butyl)-5-fluoro-N-(3-(3-fluoro-2-methyl- 8-morpholinoimidazo[1,2-a]pyridin-6-yl)-4- methylphenyl)-1H-pyrazole-4-carboxamide::US11814384, Example 275

SMILES Cc1nc2c(cc(cn2c1F)-c1cc(C(=O)Nc2cnn(c2F)C(C)(C)C)c(F)cc1C)N1CCOCC1

InChI Key InChIKey=VTFNCQJGPJFHLE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 635450   

TargetSerine/threonine-protein kinase B-raf(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM635450(1-(tert-Butyl)-5-fluoro-N-(3-(3-fluoro-2-methyl- 8...)
Affinity DataIC50: 1nMAssay Description:Small molecule inhibition of the BRAF kinases was measured using ADP-Glo assay. In the assay, ADP is converted to ATP in the presence of test kinase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2024
Entry Details
US Patent