BDBM635491 US11814388, Compound 6

SMILES O=S(=O)(Nc1ccc(Nc2ncnc3[nH]ccc23)cc1)c1ccccc1

InChI Key InChIKey=HFPZHQLESGVWLH-UHFFFAOYSA-N

Data  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 635491   

TargetAurora kinase B(Human)TBA
LigandPNGBDBM635491(US11814388, Compound 6 | US12410173, Compound 6)
Affinity DataKd:  240nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetAurora kinase B(Human)TBA
LigandPNGBDBM635491(US11814388, Compound 6 | US12410173, Compound 6)
Affinity DataKd:  240nMAssay Description:Binding affinity to human partial length AURKB (D25 to A303 residues) expressed in mammalian system assessed as dissociation constant by DiscoverX ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetAurora kinase B(Human)TBA
LigandPNGBDBM635491(US11814388, Compound 6 | US12410173, Compound 6)
Affinity DataKd:  240nMAssay Description:Compounds 2-9 were evaluated in an ADP detection assay externally using the Kinomescan KdELECT platform from Discover X.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2024
Entry Details
US Patent

LigandPNGBDBM635491(US11814388, Compound 6 | US12410173, Compound 6)
Affinity DataKd:  710nMAssay Description:Binding affinity to human partial length EGFR (R669 to V1011 residues) L858R mutant expressed in bacterial expression system assessed as dissociation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM635491(US11814388, Compound 6 | US12410173, Compound 6)
Affinity DataKd:  710nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM635491(US11814388, Compound 6 | US12410173, Compound 6)
Affinity DataKd:  710nMAssay Description:Compounds 2-9 were evaluated in an ADP detection assay externally using the Kinomescan KdELECT platform from Discover X.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2024
Entry Details
US Patent

TargetAurora kinase A(Human)TBA
LigandPNGBDBM635491(US11814388, Compound 6 | US12410173, Compound 6)
Affinity DataKd:  2.10E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetAurora kinase A(Human)TBA
LigandPNGBDBM635491(US11814388, Compound 6 | US12410173, Compound 6)
Affinity DataKd:  2.10E+3nMAssay Description:Compounds 2-9 were evaluated in an ADP detection assay externally using the Kinomescan KdELECT platform from Discover X.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2024
Entry Details
US Patent

LigandPNGBDBM635491(US11814388, Compound 6 | US12410173, Compound 6)
Affinity DataIC50: 2.16E+3nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell survivalMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM635491(US11814388, Compound 6 | US12410173, Compound 6)
Affinity DataKd:  1.50E+4nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM635491(US11814388, Compound 6 | US12410173, Compound 6)
Affinity DataKd:  1.50E+4nMAssay Description:Binding affinity to wild type human EGFR partial length (R669 to V1011 residues) expressed in bacterial expression system assessed as dissociation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM635491(US11814388, Compound 6 | US12410173, Compound 6)
Affinity DataKd:  1.50E+4nMAssay Description:Compounds 2-9 were evaluated in an ADP detection assay externally using the Kinomescan KdELECT platform from Discover X.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2024
Entry Details
US Patent

LigandPNGBDBM635491(US11814388, Compound 6 | US12410173, Compound 6)
Affinity DataIC50: 1.55E+4nMAssay Description:Inhibition of EGFR (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell survivalMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details