BDBM635981 (1R,2S)-2-(3-{[5-(difluoromethoxy)-6-(morpholin-4-yl)pyrimidin-4-yl]amino}-1H-indazol-6-yl)-5'-methoxyspiro[cyclopropane-1,3'-indol]-2'(1'H)-one::US20230365537, Example 109

SMILES COc1ccc2c(c1)[C@]1(C[C@H]1c1ccc3c(Nc4ncnc(N5CCOCC5)c4OC(F)F)n[nH]c3c1)C(=O)N2

InChI Key InChIKey=RYPUUVHGRHVJCP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 635981   

TargetSerine/threonine-protein kinase PLK4(Human)
Oric Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 635981BDBM635981(US20230365537, Example 109 | (1R,2S)-2-(3-{[5-(dif...)
Affinity DataIC50: 6.76nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2024
Entry Details
US Patent

TargetAurora kinase B(Human)
Oric Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 635981BDBM635981(US20230365537, Example 109 | (1R,2S)-2-(3-{[5-(dif...)
Affinity DataIC50: 7.48E+4nMAssay Description:Activity of human recombinant Aurora B (ThermoFisher, cat #PR9210B) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2024
Entry Details
US Patent

TargetAurora kinase A(Human)
Oric Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 635981BDBM635981(US20230365537, Example 109 | (1R,2S)-2-(3-{[5-(dif...)
Affinity DataIC50: 3.38E+5nMAssay Description:Activity of human recombinant Aurora A (ThermoFisher, cat #PR5935A) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2024
Entry Details
US Patent