BDBM636125 3-[6-methoxy-5-({6-[(1R,2S)-5'-methoxy-2'-oxo-1',2'-dihydrospiro[cyclopropane-1,3'-indol]-2-yl]-1H-indazol-3-yl}amino)pyrazin-2-yl]-1lambda6-thietane-1,1-dione::US20230365537, Example 254

SMILES COc1ccc2c(c1)[C@]1(C[C@H]1c1ccc3c(Nc4ncc(C5CS(=O)(=O)C5)nc4OC)n[nH]c3c1)C(=O)N2

InChI Key InChIKey=XSXNOQJYDZWMGX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 636125   

TargetSerine/threonine-protein kinase PLK4(Human)
Oric Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 636125BDBM636125(US20230365537, Example 254 | 3-[6-methoxy-5-({6-[(...)
Affinity DataIC50: 5.19nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2024
Entry Details
US Patent

TargetAurora kinase B(Human)
Oric Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 636125BDBM636125(US20230365537, Example 254 | 3-[6-methoxy-5-({6-[(...)
Affinity DataIC50: 499nMAssay Description:Activity of human recombinant Aurora B (ThermoFisher, cat #PR9210B) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2024
Entry Details
US Patent

TargetAurora kinase A(Human)
Oric Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 636125BDBM636125(US20230365537, Example 254 | 3-[6-methoxy-5-({6-[(...)
Affinity DataIC50: 1.55E+3nMAssay Description:Activity of human recombinant Aurora A (ThermoFisher, cat #PR5935A) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2024
Entry Details
US Patent