BDBM636311 US20230365546, Compound 94

SMILES C[C@H](NC(=O)c1cn(C)c2ccc(cc12)-c1ccn2nc(NC(=O)C3CC3)nc2c1)c1cccc(F)c1

InChI Key InChIKey=MMHXIUIFLQILFX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 636311   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Origiant Pharmaceutical

US Patent
LigandPNGBDBM636311(US20230365546, Compound 94)
Affinity DataIC50: 5.5nMAssay Description:In vitro kinase assays were conducted using Kinase Profiler services provided by Eurofins. The experimental method was as follows: the small molecule...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2024
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Origiant Pharmaceutical

US Patent
LigandPNGBDBM636311(US20230365546, Compound 94)
Affinity DataIC50: 15nMAssay Description:Inhibition of human RIPK1 (1 to 294 residues) preincubated for 15 mins followed by [gamma-33P]ATP addition and measured after 40 mins by scintillatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM636311(US20230365546, Compound 94)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of RIPK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM636311(US20230365546, Compound 94)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of RIPK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM636311(US20230365546, Compound 94)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of RIPK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed