BDBM638238 US11834453, Example 341

SMILES O[C@H]1[C@H]2CC[C@@H]1CN(C2)c1ncc2ncnc(Nc3ccc(Oc4ccn5ncnc5c4)c(Cl)c3)c2n1

InChI Key InChIKey=WMWKRGCJKFXKSB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 638238   

LigandPNGBDBM638238(US11834453, Example 341)
Affinity DataIC50: 12.7nMAssay Description:This synthesized DNA fragment was subsequently cloned into the baculovirus transfer vector, pAcSG2, between the NcoI and NotI sites. The resulting pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2024
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Array Biopharma

US Patent
LigandPNGBDBM638238(US11834453, Example 341)
Affinity DataIC50: 20.7nMAssay Description:The kinases were incubated with 250 nM TK-substrate biotin (CisBio, part of cat #62TK0PEC) at 1 mM ATP along with test compounds in a buffer consisti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2024
Entry Details
US Patent