BDBM639829 US20230391786, Example 298

SMILES Clc1ccc2c(-c3cn[nH]c3)c3CN(CCn3c2c1Cl)C(=O)CC1COCCOC1

InChI Key InChIKey=ZFNRDYGGKGBIKI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 639829   

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639829(US20230391786, Example 298)
Affinity DataIC50: 23.4nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent