BDBM641227 US11845723, Example 121

SMILES CN(c1cccc(c1)-c1ccco1)c1nc2nncn2c2ccccc12

InChI Key InChIKey=QQKDAJUQEQHBKF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 641227   

TargetDiacylglycerol kinase alpha(Human)
Gilead Sciences

US Patent
LigandPNGBDBM641227(US11845723, Example 121)
Affinity DataIC50: 12nMAssay Description:Table 5: The IC50 value was calculated via a regression analysis of the inhibition rate (%) measured from the intensity of the luminescence at each c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2024
Entry Details
US Patent

TargetDiacylglycerol kinase alpha(Human)
Gilead Sciences

US Patent
LigandPNGBDBM641227(US11845723, Example 121)
Affinity DataIC50: 21.4nMAssay Description:Table 6: Alternatively, the enzymatic activity of human DGKα was monitored in a biochemical assay in the presence or absence of compounds and us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2024
Entry Details
US Patent