BDBM644452 5-(2-(4-((3-Chloro-4-(trifluoromethoxy)benzyl)amino)butoxy)ethoxy)benzo[c][2,6]naphthyridine-8-carboxylic Acid::US11866436, Example 46

SMILES c1cc(c(cc1CNCCCCOCCOc2c3ccncc3c4ccc(cc4n2)C(=O)O)Cl)OC(F)(F)F

InChI Key InChIKey=ZXBOCEMSOANKPH-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 644452   

TargetCasein kinase II subunit alpha [2-329](Human)
Cambridge Enterprise

US Patent
LigandChemical structure of BindingDB Monomer ID 644452BDBM644452(US11866436, Example 46 | 5-(2-(4-((3-Chloro-4-(tri...)
Affinity DataIC50: 0.404nMAssay Description:Final assay conditions comprised 0.2 nM CK2α, 50 μM peptide substrate (RRRADDSDDDDD), 15 μM ATP in 1× reaction buffer (40 mM Tris pH7....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2024
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetDual specificity protein kinase CLK2(Human)
Cambridge Enterprise

US Patent
LigandChemical structure of BindingDB Monomer ID 644452BDBM644452(US11866436, Example 46 | 5-(2-(4-((3-Chloro-4-(tri...)
Affinity DataIC50: 132nMAssay Description:The assay was conducted in the same way as described for CK2α, with final assay conditions comprising 20 nM CLK2 (Carna Biosciences-04-127), 50 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2024
Entry Details
US Patent