BDBM652431 6-[(4-{[(1-methylpiperidin-4-yl)oxy]methyl}phenyl)methoxy]isoquinolin-1-amine::US20240059691, Example 1011

SMILES CN1CCC(CC1)OCc1ccc(COc2ccc3c(N)nccc3c2)cc1

InChI Key InChIKey=QDUVSTRMUNWXBX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 652431   

TargetCoagulation factor XII(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652431BDBM652431(US20240059691, Example 1011 | 6-[(4-{[(1-methylpip...)
Affinity DataIC50: 6.50E+3nMAssay Description:In vitro inhibition of Factor XIIa was determined using an IC50 assay based on standard literature methods (see e.g Baeriswyl et al., ACS Chem. Biol....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652431BDBM652431(US20240059691, Example 1011 | 6-[(4-{[(1-methylpip...)
Affinity DataIC50: 2.50E+4nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent