BDBM652448 6-N-[(6-{[2-(trifluoromethyl)-5H,6H,7H,8H-imidazo[1,2-a]pyridin-7-yl]methoxy}pyridin- 3-yl)methyl]isoquinoline-1,6-diamine::US20240059691, Example 1028

SMILES Nc1nccc2cc(NCc3ccc(OCC4CCn5cc(nc5C4)C(F)(F)F)nc3)ccc12

InChI Key InChIKey=PXSYVGNIQPEKEG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 652448   

TargetCoagulation factor XII(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652448BDBM652448(US20240059691, Example 1028 | 6-N-[(6-{[2-(trifluo...)
Affinity DataIC50: 2.00E+3nMAssay Description:In vitro inhibition of Factor XIIa was determined using an IC50 assay based on standard literature methods (see e.g Baeriswyl et al., ACS Chem. Biol....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent