BDBM652485 6-N-[(6-{[(1R,5S,6S)-3-methyl-3-azabicyclo[3.1.0]hexan-6-yl]methoxy}pyridin-3- yl)methyl]isoquinoline-1,6-diamine::US20240059691, Example 1175

SMILES CN1C[C@H]2[C@@H](COc3ccc(CNc4ccc5c(N)nccc5c4)cn3)[C@H]2C1

InChI Key InChIKey=LIVAVELEINFPRB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 652485   

TargetCoagulation factor XII(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652485BDBM652485(US20240059691, Example 1175 | 6-N-[(6-{[(1R,5S,6S)...)
Affinity DataIC50: 650nMAssay Description:In vitro inhibition of Factor XIIa was determined using an IC50 assay based on standard literature methods (see e.g Baeriswyl et al., ACS Chem. Biol....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent