BDBM652494 4-fluoro-N5-((6-(((1-methylpiperidin-4-yl)methyl)amino)pyridin-3- yl)methyl)isoquinoline-1,5-diamine::US20240059691, Example 1194

SMILES CN1CCC(CNc2ccc(CNc3cccc4c(N)ncc(F)c34)cn2)CC1

InChI Key InChIKey=JIJJXSHEUUVQGS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 652494   

TargetCoagulation factor XII(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652494BDBM652494(US20240059691, Example 1194 | 4-fluoro-N5-((6-(((1...)
Affinity DataIC50: 6.50E+3nMAssay Description:In vitro inhibition of Factor XIIa was determined using an IC50 assay based on standard literature methods (see e.g Baeriswyl et al., ACS Chem. Biol....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652494BDBM652494(US20240059691, Example 1194 | 4-fluoro-N5-((6-(((1...)
Affinity DataIC50: 7.00E+4nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent