BDBM652525 6-methyl-N-((6-(((1-methylpiperidin-4-yl)methyl)amino)pyridin-3-yl)methyl)-7H- pyrrolo[2,3-d]pyrimidin-4-amine::US20240059691, Example 1254

SMILES CN1CCC(CNc2ccc(CNc3ncnc4[nH]c(C)cc34)cn2)CC1

InChI Key InChIKey=NWYVADAYUACKJE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 652525   

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652525(US20240059691, Example 1254 | 6-methyl-N-((6-(((1-...)
Affinity DataIC50: 3nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
Go to US Patent

TargetCoagulation factor XII(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652525(US20240059691, Example 1254 | 6-methyl-N-((6-(((1-...)
Affinity DataIC50: 2.50E+4nMAssay Description:In vitro inhibition of Factor XIIa was determined using an IC50 assay based on standard literature methods (see e.g Baeriswyl et al., ACS Chem. Biol....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
Go to US Patent