BDBM652530 4-(((6-(((1-methylpiperidin-4-yl)methyl)amino)pyridin-3-yl)methyl)amino)-1H- pyrrolo [2,3-b]pyridine-6-carboxylic acid::US20240059691, Example 1263

SMILES CN1CCC(CNc2ccc(CNc3cc(C(=O)O)nc4[nH]ccc34)cn2)CC1

InChI Key InChIKey=NEZXKNOMWDQBLX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 652530   

TargetCoagulation factor XII(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652530BDBM652530(US20240059691, Example 1263 | 4-(((6-(((1-methylpi...)
Affinity DataIC50: 2.50E+4nMAssay Description:In vitro inhibition of Factor XIIa was determined using an IC50 assay based on standard literature methods (see e.g Baeriswyl et al., ACS Chem. Biol....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652530BDBM652530(US20240059691, Example 1263 | 4-(((6-(((1-methylpi...)
Affinity DataIC50: 7.00E+4nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent