BDBM652536 1-(5-(((1-amino-4-chloroisoquinolin-6-yl)amino)methyl)pyridin-2-yl)-6',7'- dihydrospiro[azetidine-3,5'-pyrrolo[1,2-a]imidazol]-7'-ol::US20240059691, Example 1270

SMILES Nc1ncc(Cl)c2cc(NCc3ccc(nc3)N3CC4(C3)CC(O)c3nccn43)ccc12

InChI Key InChIKey=GVDJCUMMMLEGOV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 652536   

TargetCoagulation factor XII(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652536BDBM652536(US20240059691, Example 1270 | 1-(5-(((1-amino-4-ch...)
Affinity DataIC50: 2.50E+4nMAssay Description:In vitro inhibition of Factor XIIa was determined using an IC50 assay based on standard literature methods (see e.g Baeriswyl et al., ACS Chem. Biol....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652536BDBM652536(US20240059691, Example 1270 | 1-(5-(((1-amino-4-ch...)
Affinity DataIC50: 7.00E+4nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent