BDBM652575 (R*)-2-chloro-N-((4-methyl-6-(8-methyl-3-(trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)pyridin-3-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-4- amine::US20240059691, Example 1315

SMILES Cc1cc(N2CCn3c(nnc3C(F)(F)F)[C@H]2C)ncc1CNc1ccnc2[nH]c(Cl)cc12

InChI Key InChIKey=CBWMWWWCCMJVQL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 652575   

TargetCoagulation factor XII(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652575BDBM652575(US20240059691, Example 1315 | (R*)-2-chloro-N-((4-...)
Affinity DataIC50: 2.50E+4nMAssay Description:In vitro inhibition of Factor XIIa was determined using an IC50 assay based on standard literature methods (see e.g Baeriswyl et al., ACS Chem. Biol....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent