BDBM652592 (R)-N5-((4-methyl-6-(6-methyl-3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3- a]pyrazin-7(8H)-yl)pyridin-3-yl)methyl)isoquinoline-1,5-diamine::US20240059691, Example 1342

SMILES C[C@@H]1Cn2c(CN1c1cc(C)c(CNc3cccc4c(N)nccc34)cn1)nnc2C(F)(F)F

InChI Key InChIKey=VIHAKVZBNUYTPP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 652592   

TargetCoagulation factor XII(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652592BDBM652592(US20240059691, Example 1342 | (R)-N5-((4-methyl-6-...)
Affinity DataIC50: 55nMAssay Description:In vitro inhibition of Factor XIIa was determined using an IC50 assay based on standard literature methods (see e.g Baeriswyl et al., ACS Chem. Biol....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent