BDBM652644 N5-((1-(2-(1-methylpiperidin-4-yl)ethyl)-1H-pyrazol-4-yl)methyl)isoquinoline-1,5- diamine::US20240059691, Example 3255

SMILES CN1CCC(CCn2cc(CNc3cccc4c(N)nccc34)cn2)CC1

InChI Key InChIKey=DLUKPZQRIWFFDH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 652644   

TargetCoagulation factor XII(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652644BDBM652644(US20240059691, Example 3255 | N5-((1-(2-(1-methylp...)
Affinity DataIC50: 650nMAssay Description:In vitro inhibition of Factor XIIa was determined using an IC50 assay based on standard literature methods (see e.g Baeriswyl et al., ACS Chem. Biol....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent