BDBM652656 6-N-[[2-[(3-methyl-3-azabicyclo[3.2.1]octan-8-yl)methoxy]-4- pyridyl]methyl]isoquinoline-1,6-diamine::US20240059691, Example 4270

SMILES CN1CC2CCC(C1)C2COc1cc(CNc2ccc3c(N)nccc3c2)ccn1

InChI Key InChIKey=VZCLQKXKPFPMJM-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 652656   

TargetCoagulation factor XII(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652656BDBM652656(US20240059691, Example 4270 | 6-N-[[2-[(3-methyl-3...)
Affinity DataIC50: 55nMAssay Description:In vitro inhibition of Factor XIIa was determined using an IC50 assay based on standard literature methods (see e.g Baeriswyl et al., ACS Chem. Biol....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

TargetCoagulation factor X(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652656BDBM652656(US20240059691, Example 4270 | 6-N-[[2-[(3-methyl-3...)
Affinity DataIC50: 55nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

TargetKallikrein-1(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652656BDBM652656(US20240059691, Example 4270 | 6-N-[[2-[(3-methyl-3...)
Affinity DataIC50: 650nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

TargetProthrombin(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652656BDBM652656(US20240059691, Example 4270 | 6-N-[[2-[(3-methyl-3...)
Affinity DataIC50: 2.00E+3nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652656BDBM652656(US20240059691, Example 4270 | 6-N-[[2-[(3-methyl-3...)
Affinity DataIC50: 6.50E+3nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent