BDBM652679 4-chloro-6-N-[(2-{[(1-isopropylpiperidin-4-yl)oxy]methyl}pyridin-4- yl)methyl]isoquinoline-1,6-diamine::US20240059691, Example 4296

SMILES CC(C)N1CCC(CC1)OCc1cc(CNc2ccc3c(N)ncc(Cl)c3c2)ccn1

InChI Key InChIKey=TVXGWIZPUXEVHQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 652679   

TargetCoagulation factor XII(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652679BDBM652679(US20240059691, Example 4296 | 4-chloro-6-N-[(2-{[(...)
Affinity DataIC50: 2.00E+3nMAssay Description:In vitro inhibition of Factor XIIa was determined using an IC50 assay based on standard literature methods (see e.g Baeriswyl et al., ACS Chem. Biol....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent