BDBM652714 6-N-[(2-{5H,6H,7H,8H-imidazo[1,2-a]pyridin-7-ylmethoxy}pyridin-4-yl)methyl]-2,7- naphthyridine-1,6-diamine::US20240059691, Example 4429

SMILES Nc1nccc2cc(NCc3ccnc(OCC4CCn5ccnc5C4)c3)ncc12

InChI Key InChIKey=QYAKYTAQLVVGGM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 652714   

TargetCoagulation factor XII(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652714BDBM652714(US20240059691, Example 4429 | 6-N-[(2-{5H,6H,7H,8H...)
Affinity DataIC50: 2.00E+3nMAssay Description:In vitro inhibition of Factor XIIa was determined using an IC50 assay based on standard literature methods (see e.g Baeriswyl et al., ACS Chem. Biol....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652714BDBM652714(US20240059691, Example 4429 | 6-N-[(2-{5H,6H,7H,8H...)
Affinity DataIC50: 6.50E+3nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent