BDBM652727 (R*)-4-chloro-N6-((2-((2-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-7- yl)methoxy)pyridin-4-yl)methyl)isoquinoline-1,6-diamine::US20240059691, Example 4442

SMILES Cc1cn2CC[C@@H](COc3cc(CNc4ccc5c(N)ncc(Cl)c5c4)ccn3)Cc2n1

InChI Key InChIKey=CSNSELBEUILYAV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 652727   

TargetCoagulation factor XII(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652727BDBM652727(US20240059691, Example 4442 | (R*)-4-chloro-N6-((2...)
Affinity DataIC50: 650nMAssay Description:In vitro inhibition of Factor XIIa was determined using an IC50 assay based on standard literature methods (see e.g Baeriswyl et al., ACS Chem. Biol....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652727BDBM652727(US20240059691, Example 4442 | (R*)-4-chloro-N6-((2...)
Affinity DataIC50: 2.50E+4nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent