BDBM652743 N-methyl-6-(methyl(2-((1-methylpiperidin-4-yl)methoxy)pyridin-4- yl)amino)isoquinoline-8-carboxamide::US20240059691, Example 4463

SMILES CNC(=O)c1cc(cc2ccncc12)N(C)c1ccnc(OCC2CCN(C)CC2)c1

InChI Key InChIKey=OPOOBCSVRFDHBZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 652743   

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652743BDBM652743(US20240059691, Example 4463 | N-methyl-6-(methyl(2...)
Affinity DataIC50: 7.00E+4nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

TargetCoagulation factor XII(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652743BDBM652743(US20240059691, Example 4463 | N-methyl-6-(methyl(2...)
Affinity DataIC50: 7.50E+4nMAssay Description:In vitro inhibition of Factor XIIa was determined using an IC50 assay based on standard literature methods (see e.g Baeriswyl et al., ACS Chem. Biol....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent