BDBM652749 8-fluoro-N5-((2-((1-methylpiperidin-4-yl)methoxy)pyridin-4-yl)methyl)isoquinoline-1,5- diamine::US20240059691, Example 4469

SMILES CN1CCC(COc2cc(CNc3ccc(F)c4c(N)nccc34)ccn2)CC1

InChI Key InChIKey=LSKPXPLWMKWCHU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 652749   

TargetCoagulation factor XII(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652749BDBM652749(US20240059691, Example 4469 | 8-fluoro-N5-((2-((1-...)
Affinity DataIC50: 6.50E+3nMAssay Description:In vitro inhibition of Factor XIIa was determined using an IC50 assay based on standard literature methods (see e.g Baeriswyl et al., ACS Chem. Biol....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652749BDBM652749(US20240059691, Example 4469 | 8-fluoro-N5-((2-((1-...)
Affinity DataIC50: 7.00E+4nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent